In this study, we sought to improve ligament
healing by modulating the inflammatory response after acute injury through the
neutralization of Interleukin-17 (IL-17), which we hypothesized would decrease
inflammatory cell infiltration and cytokine production.
Administration of
an Interleukin-17 neutralizing antibody (IL-17 NA) immediately following a rat medial
collateral ligament (MCL) transection resulted in alterations in inflammatory
cell populations and cytokine expression within the healing ligament, but did
not reduce inflammation.
Specifically, treatment resulted in a decrease
in M2 (antiinflammatory) macrophages, an increase in T cells, and an increase
in the levels of IL-2, IL-6, and IL-12 in the MCL 7 days post injury.
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