like B lymphocytes that differentiate in the
bone marrow (BM), T lymphocytes need the special 3D epithelial microenvironment
of the thymus to develop properly, in which they establish intimate interactions
with Thymic Epithelial Cells.
Thus, whereas
B lymphocytes derive from haematopoietic progenitor cells in the BM, T
cells need more- or-less committed lymphoid progenitors to colonize the adult
thymus through blood vessels because this organ lacks auto-renewing progenitor
cells.
Mechanisms involved in the selective migration
of BM progenitor cells have been largely associated with attracting chemokines
and molecules involved in lymphoid cell migration through vascular endothelia, such
as integrins and selectins.
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