Mesenchymal stem cells (MSC) represent a promising cellular
therapy for the treatment of immune-related conditions due to their
immunomodulatory properties, which include the capacity to inhibit the
proliferation and function of T-cells.
Despite the fact that MSC have been the subject of intense
investigation as therapeutic agents for diseases
in which cellular immune response is exacerbated, the underlying mechanisms
of how MSC exert their T cell suppressive properties remain to be fully
understood.
Eph surface tyrosine kinase receptors and their ephrin
ligands are involved in T-cell development, maturation, activation and
proliferation. Recent findings have demonstrated Eph/ephrin interactions as
potential mechanisms mediating human MSC inhibition of activated T-cells.
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