Duchenne muscular dystrophy (DMD) is the most
common type of muscular dystrophy, which is also regarded as a severe muscle
disease with an incidence of 1 in 3,500 live male newborns in the world. The
leading cause is dyctrophin gene mutations, which lose regulation of the muscle
protein.
Cell death, progressive damage of muscle
fibers, oxidative stress, and inflammation are the remarkable characteristics
of DMD in humans and mdx mice. Glucocorticoid play a role on boosting
muscle function and strength in a short time in DMD therapy, but it is not
effective and with plentiful side effects, like hypertension, diabetes,
mood/behavioral affection for a long time using.
Therefore, there is not noticeably effective method
for treatment of DMD yet.Nrf2 (NF-E2 related factor 2) is one of the momentous
transcription factors, which exists in biological body and affect genes
expression of numerous oxidative stress proteins, detoxifying enzymes and
antioxidant enzymes.
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