The interaction between infectious pathogens
and the immune system has been a focus of research for many years. However, the
failure of re-recognition or immune memory of infectious
pathogen remains a clear mystery A memory B cell defect coupled with low levels
of C1-INH and/or C1-INH function-failure of both the innate and adaptive immune
components-may lead to persistent unresolved infection.
Here we present 3 case studies that explore
the abnormal immune response that may lead to persistent infection. These cases
offer possible clarification of a longstanding clinical observation that some
patients may develop a post infectious syndrome that includes various
neurological symptoms and unusual fatigue.
These patients may have positive serology seen
only during acute infectious phase and have a documented positive PCR,
suggesting active presence of the pathogen. The unusual presentation is
prolonged and irreversible.
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