The paranasal sinuses are rare sites for
origination of primary Non-Hodgkin’s lymphoma (NHL). Most often, primary
paranasal lymphomas are diffuse large B-cell lymphomas (DLBCL) associated with
a poor prognosis. This paper describes an uncommon case of ethmoid sinus lymphoma with lateral displacement of
the left orbit
and involvement of the nasal vault, skull base, and frontal sinuses.
Excisional biopsy and flow cytometry findings
favored the diagnosis of DLBCL, non-germinal center type. Moreover, CT showed
an epigastric mass and enlarged lymph nodes along the left iliac chain and
spleen. Radiation therapy was immediately started and the patient achieved
significant symptomatic relief after four treatments.
Accurate diagnosis of extranodal NHL lymphomas
through a thorough history, physical exam, imaging, and immunopathology is
necessary to initiate prompt treatment of this rare, aggressive disease.
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