Acinetobacter baumannii, Pseudomonas
aeruginosa and Klebsiella pneumonia have evolved as a group of co-existing
multidrug resistant nosocomial pathogens spreading worldwide.
Overuse of antibiotics has led to the emergence
of pan drug resistant bacterial strains and has made all antimicrobial agents
superfluous including carbapenems and even the last resort antibiotic-colistin,
resulting in high mortality rates among the hospitalized patients.
Vaccination is highly effective and
successfully used strategy that reduces the incidence of infectious diseases,
yet efforts towards development of vaccines for nosocomial infections are
scant. In this direction, a broad spectrum vaccine is the futuristic need
providing protection not only against A. baumannii but against the whole group
of co-existing nosocomial pathogens.
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