Atopic dermatitis (AD) is an inflammatory skin
disease with eczematous pruritic lesions. Topical corticosteroids are the most
widely used and the mainstay of treatment for AD. There are some studies that
percutaneous systemic absorption of topical steroids may occur and lead to
suppression of hypothalamic-pituitaryadrenal axis (HPAA).
However, almost in all of these studies,
“basic” HPAA function (before application of topical steroids) was not
evaluated. The aim of this study was to
investigate basal serum cortisol, adrenocorticotropic hormone (ACTH), and
IgE levels in patients with AD and their correlation with disease severity.
Levels of basal serum cortisol, ACTH, and IgE
were assessed by ELISA in 31 patients with AD and 31 control subjects. Clinical
severity of AD was evaluated by the SCORAD (SCORing Atopic Dermatitis) index.
Results: Data analysis showed no statistical difference for basal serum
cortisol and ACTH levels between two groups.
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