Proper cell
migrations are tightly regulated in unicellular and multicellular organisms.
For example, cell migration is a critical process in our immune system that
will determine the development of different specific immune
cell types, promote immune surveillance and the proper mounting of host defence
against invading microbes.
Natural killer
cells (NK) are granulocytic lymphocytes derived from bone marrow hematopoietic
stem cells. The molecular mechanism(s) that govern NK differentiation remains
unclear.
Soluble factors
(such as IL-15, SCF, Flt3L and IL-7), transcription factors (e.g. Ikaros,
E4BP4), and microenvironment of bone marrow are involved in this coordinated NK
differentiation process.
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