Tuberculosis is a
leading worldwide health problem. The latent, symptom-free stage of tuberculous
infection is characterized by the formation of granulomas, specific aggregates
of immune cells, predominantly macrophages, containing mycobacteria.
The apoptotic
death of macrophages containing mycobacteria is considered the main
mechanism by which animals and human organisms oppose tuberculous infection
and control its development.
Previously, we
have comparedMycobacterium-host cell relationships in individual granuloma
cells from mice with latent tuberculous infection and cells from mouse bone
marrow and peritoneal cultures infected with BCG vaccine in vitro and shown
that increased death rates were revealed for macrophages heavily loaded with
mycobacteria after acute BCG infection in vitro.
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