In the last
decade, experimental research has intensely focused on metabolic reprogramming
of tumor cells, which contributes to cancer cell adaptation and survival in
different and hostile microenvironments.
Metabolic
reprogramming consists of the switch of tumor cells from aerobic or anaerobic
glycolysis to oxidative phosphorylation. A comprehensive vision of the metabolic
scenario involving functionally different tumor cell subpopulations was
proposed as a necessary premise to the design of new strategies of diagnosis
and therapy.
Special focus has been put on the role of
acidosis of certain tumor regions, a very important although frequently
neglected aspect.
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