Rheumatoid arthritis (RA) is a
chronic inflammatory autoimmune disease of the joints and other body organs,
which 1 % of the human population is affected. RA induced in the fourth and
fifth decades of life and in women is more common. Kelussiao doratissima
contains compounds such as flavonoids, mainly aggregated in the inflorescence
and stems of Kelussia, has anti-inflammatory effects. Present study aimed to
investigate the anti-inflammatory effect of Kelussia odoratissima on rheumatoid
arthritis induced in Wistar rats.
A total of 30 female Wistar rats
using subcutaneous injection of complete Freund's adjuvant has been induced and
were randomly divided into five groups containing negative control (no
treatment), positive control (receiving indomethacin (3mg/ Kg) and three
rheumatoid arthritis group receiving three different doses (100,200and
300mg/kg) of hydroalcoholic Kelussia odoratissima extract. material injection
were tested in the animals for 10 days.
The symptoms of Rheumatoid
arthritis were evaluated according to standardized scoring method at paw and
double-blind for the different categories daily. CRP levels were measured and
Data were analyzed using the SPSS statistical program (version 17 for Windows).
In all the cases for comparison between different groups, Mann-Whitney U-test
was used.
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