Jatropha Curcas Linn can Reduce the Expression of Hsp70 that will Result in Reduced Errors in Protein Folding and Promotion of Normal Protein Function in Proliferation and Apoptosis

Jatropha curcas Linn as a local plant have phytochemical contents, like anti-inflammatory and cytotoxicity properties of phenolic extract. Leaf of J.curcas contents higher phenolic compound, flavonoid and saponin. Application of different varieties of J.curcas in traditional medicine had been reported.

However, information regarding the bioactive compounds and the therapeutic activities is still lacking. These studies suggest that components from J.curcas may have anticancer function and potentially be useful for prevention and treatment strategies.All organisms respond to heat (heat shock response) by upregulating specific heat shock or stress proteins.

Research over the last decade has shown that increased expression of heat shock protein 70 (Hsp70) plays a role in protein folding errors from denaturised proteins and new protein translation, causing proteins to function abnormally. Multiple hits – multiple steps – multiple stage stressors may experience distress and express Hsp70, among other cellular factors, to inhibit cell proliferation and enhance apoptosis.

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