Biological
activities of the methanolic was under study. Leaf extracts that contains
methanolic acid of Jatropha curcas showed the highest antioxidant activity.
Other research in cytotoxicity assay results indicated the anticancer
therapeutic property of the root extract against human colon adenocarcinoma
(HT-29) cell line but its cytotoxic effect on human hepatocyte (Chang cell) was
high.
Macrophages
can be activated to become neoplasticidal by interaction with a substance
filled immune modulators. Neoplasticidal macrophages can recognize and destroy
neoplastic cells in vitro and in vivo. Although the exact
mechanism by which macrophages discriminate between neoplastic and normal cells
is unknown, it is independent of neoplastic cell characteristics such as
immunogenicity, metastatic potential, and sensitivity to drugs.
Moreover,
macrophage destruction of neoplastic cells apparently is not associated with
the development of neoplastic cell resistance. Macrophages are found in
association with neoplasm in a definable pattern, suggesting that the most
direct way to achieve macrophage-mediated neoplasm regression is in situ
macrophage activation.
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