Polysaccharides
or heteroglycan isolated from fungal species have attained wide recognition for
their immune modulating functions. However, there exists a
significant relationship in the structural and functional activity of this
molecule.
In this
commentary, we focus on a well characterized heteroglycan isolated from the
mycelia of Pleurotus ostreatus which have been shown to drive immune
stimulation in tumor bearing mice.
The heteroglycan
possessed high molecular weight and was primarily composed of glucose, mannose
and fucose in a 3:2:1 ratio with major β- linkages in the repeating chain. The
molecule also exhibited triple helical conformation in solutions.
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