Recently, the
evidence for platelet association with allergic diseases has been established
by many researches. Activated platelets contribute to airway hyper reactivity,
bronchoconstriction, airway inflammation and airway remodeling in asthmatic patients.
We aimed to
clarify platelet activation and key molecules on platelets, which are mainly
associated with the mechanism underlying aspirin-exacerbated respiratory
disease.
Aspirin-exacerbated
respiratory disease (AERD) is characterized by the triad of asthma, nasal
polyposis, and hypersensitivity to aspirin and other cyclooxygenase (COX)-1
inhibitors.
Urinary
leukotriene (LT) E4 (uLTE4) levels are 3-4 fold higher in AERD patients than in
ATA patients, which further increase after aspirin-induced reaction in AERD
patients.
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