Colorectal cancer
represents one of the most frequent human neoplasia in Western Countries.
Patient prognosis dramatically decreases in advanced tumour stage, when tumour
cells acquire the capability to leave the primary tumour site and invade lymph
nodes or distant organs.
Chemokines and
chemokine receptors have been largely demonstrated to play a crucial role in
tumour metastatic progression, influencing the leukocyte
composition of the tumour microenvironment through the
recruitment of immune cells and driving tumour cells to distant metastatic
sites.
In our recent
paper, we unexpectedly found that the concomitant expression of the chemokine
CX3CL1 (Fractalkine) and its specific receptor CX3CR1 by colorectal cancer
cells strongly enforces homotypic tumour cell adhesion, retaining cells locally
and avoiding tumour metastatic dissemination
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