Clinical and epidemiological studies have demonstrated that
macroenvironmental factors are risk factors for the development and progression
of tumor.
Macroenvironmental factors include a patient's physical,
social environment and specific psychosocial factors such as chronic
stress, depression,
and lack of social support. These observations raise intriguing questions on
the brain-cancer connection.
What are the molecules in brain linking environmental factors
to cancer? Through which pathways do these brain molecules modulate the
peripheral cancer? How do these molecules impact tumour growth and progression?
The effects and mechanisms of the macroenvironment on systemic cancer are much
less well defined, because most basic cancer research focuses on
microenvironmental factors of tumor.
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