Campylobacter
jejuni is the leading bacterial cause of human enteritis in many industrialized
countries. There is no commercial vaccine against C.
jejuni available
to date. CmeC is an
essential outer membrane component of CmeABC multidrug efflux pump that
plays a critical role in antibiotic resistance and in vivo colonization of C.
jejuni.
CmeC is prevalent
in C. jejuni strains and is dramatically induced and immunogenic in vivo.
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