Microparticles
(MPs, also known as microvesicules or ectosomes) are heterogeneous subcellular
vesicular particles (0.1-1.0 nm in diameter) released constitutively from cells
and platelets undergoing cell activation or
cell death by blebbing or shedding.
Platelet MPs are
usually the most abundant type in blood. The presence of basal levels of MPs is
common in healthy individuals, and is estimated, in peripheral blood, to range
between 5 and 50 g/ml (105-106 MPs/ml).
Numerous types of
MPs have been characterized with important physiologic effects by the detection
of different cell surface antigens reflecting their origin and activation
method.
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