NK cells are
effective in nipping the tumor cells in fringes but they are helpless in
fighting with the large and established tumors. The complex immunosuppressive
milieu present in the NK cell limits its ability to fight the microenvironment
in tumor.
Different
inhibitory receptors also try to control the functioning of the NK cell. The specific
ligands expressed on the tumor cell surface or de novo induced/up-regulated
immunostimulatory factors released during the active phases of the immune
responses exert an unwonted side effect
called “tumor adaptive immune resistance” limits the efficiency of NK cells.
When DNA
extraction and sequencing for the region of the arylsulfatase B by ABI PRISM®
3100 Genetic Analyzer was performed
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