In this study, we sought to improve ligament
healing by modulating the inflammatory response after acute injury through the
neutralization of Interleukin-17 (IL-17), which we hypothesized, would decrease inflammatory cell infiltration and cytokine production. Administration of an
Interleukin-17 neutralizing antibody (IL-17 NA) immediately following a rat
medial collateral ligament (MCL) transection resulted in alterations in inflammatory
cell populations and cytokine expression within the healing ligament, but did
not reduce inflammation. Specifically, treatment resulted in a decrease in M2 (anti-inflammatory)
macrophages, an increase in T cells, and an increase in the levels of IL-2,
IL-6, and IL-12 in the MCL 7 days post injury. IL-17NA treatment, and
subsequent immuno modulation, did not result in improved ligament healing, as
measured by collagen composition and wound size.
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