Since the characterization of CD4+CD25+ regulatory T cells (Tregs) as a specific T-cell lineage with immune regulatory function in the 1990s, approaches manipulating Treg expansion and activities have been proved potential therapeutic strategies for immune-mediated diseases. On the other hand, harnessing leukocyte migration during inflammation as a therapeutic modality for immunologic diseases has not only supported by theoretical basis but also clinically shown potential.
Whilst advances have been made in the understanding of the effector mechanisms of Treg-mediated immune suppression, the migration phenotypes as well as the anatomic sites where Tregs exert immune regulation remain obscured. In a recent study by using the footpad inflammation model and adoptive Treg-cell transfer, Huang et al. demonstrated that blockage of Treg lymph node localization abrogated the immunosuppressive function of Tregs, suggesting an indispensable role of lymph node trafficking in Treg-mediated immune regulation.
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