Growth Arrest
Specific 6 (Gas6) is a vitamin K-dependent protein, the biological activity of
which is mediated by TAM receptors, a family of Tyrosine Kinases which includes
three different members Tyro3, Axl and Mer.
TAM
receptors are also activated by Protein S, which shares structural
similarities with Gas6, but is mainly expressed in the liver and exerts an
anticoagulant effect in vivo.
Conversely, Gas6
is more widely expressed (lung, heart, kidney, intestine, endothelial cells,
bone marrow, vascular smooth muscle cells, monocytes and liver) and has much
more pleiotropic effects.
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