Cells exert
natural cytolytic activity and they are capable of eliminating the most
dangerous K562 eritroleukemia cell line. However, they need to be activated to
exert the optimum effctor to exert maximum pressure on them.
Natural
killer cells are able to eliminate the tumors that are still in formative
stage. They are however unable to eradicate the spread of well establisjed
tumors.
NK cells are also
abundant in numbers and the challenge lays picking up the right cell that can be
activated and used for immunotherapy to fight cancer. Hence, adoptive
transferred NK cell-based therapeutic protocols must choose optimal activation
strategies for the in vitro activated NK cells, and, their chemokine receptor
repertoire.
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