Thursday, 8 June 2017

Development of de novo Hemolytic Uremic Syndrome Post-Transplant and the Role of Donor Specific Antibodies

Specific Antibodies
A 66 year old female with a past medical history of end stage renal disease presumed secondary to diabetic nephropathy (no kidney biopsy performed), who underwent hemodialysis for 3 years, presented for cadaveric renal transplant.  

Her past surgical history was remarkable for failed arteriovenous fistula, appendectomy, and tonsillectomy. Her prior known sensitizing events included a prior pregnancy, one miscarriage, remote blood transfusion, but no previous transplants.

Her relevant family history included diabetes, hypertension, with no known family history of HUS or thrombotic thrombocytopenic purpura (TTP).

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