A patient
returned from Algeria showing a grade III wound (WHO standard) produced by a
dog bite, was treated with rabies nerve tissue vaccines
(NTVs) lacked the rabies immunoglobin, and developed a
visible local reaction to the vaccine.
The last WHO
position paper (2010) recommends replacing nerve-tissue vaccines with CCVs. The
nerve tissue vaccines induce more-severe adverse reaction sand are less
immunogenic than CCVs.
It should be
assessed in travellers to areas of risk, pre-exposure vaccination, and
eliminated the need to the use of rabies globulin post exposition, and avoid as
much as possible the use of of nerve-tissue vaccines.
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